Evaluation of Paraoxonase 1 Activities in Patients Infected with Hepatitis C Virus Genotype 1b and Genotype 4 in the Kayseri Province of Turkey

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Sariguzel F., KARAKÜKCÜ Ç., Kocer D., Karaman H., Karaman A., Yaman O., ...More

VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, vol.21, no.1, pp.13-16, 2015 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4274/vhd.65256
  • Journal Name: VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.13-16
  • Keywords: PON1, HCV, genotype 1b, genotype 4
  • Erciyes University Affiliated: No

Abstract

Objective: Hepatitis C virus (HCV) infection is an important cause of chronic liver disease and is associated with oxidative stress. The type of treatment given for chronic HCV infection depends on the genotype of the virus. Genotype 1b is known to be associated with poor prognosis, although knowledge about genotype 4 is not sufficient. In this study, we aimed to compare serum paraoxonase (PON1) activities in HCV genotype 1b-infected patients with those in HCV genotype 4-infected ones, and the relationship of PON1 activity with hepatic damage demonstrated as liver fibrosis.