Evaluation of Paraoxonase 1 Activities in Patients Infected with Hepatitis C Virus Genotype 1b and Genotype 4 in the Kayseri Province of Turkey

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Sariguzel F., KARAKÜKCÜ Ç., Kocer D., Karaman H., Karaman A., Yaman O., ...Daha Fazla

VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, cilt.21, sa.1, ss.13-16, 2015 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/vhd.65256
  • Dergi Adı: VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.13-16
  • Anahtar Kelimeler: PON1, HCV, genotype 1b, genotype 4
  • Erciyes Üniversitesi Adresli: Hayır

Özet

Objective: Hepatitis C virus (HCV) infection is an important cause of chronic liver disease and is associated with oxidative stress. The type of treatment given for chronic HCV infection depends on the genotype of the virus. Genotype 1b is known to be associated with poor prognosis, although knowledge about genotype 4 is not sufficient. In this study, we aimed to compare serum paraoxonase (PON1) activities in HCV genotype 1b-infected patients with those in HCV genotype 4-infected ones, and the relationship of PON1 activity with hepatic damage demonstrated as liver fibrosis.