Release of Doxorubicin's Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions

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MISIR S., Hepokur C., Kariper I. A.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, cilt.53, sa.1, ss.171-177, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5530/ijper.53.1.22
  • Dergi Adı: INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.171-177
  • Anahtar Kelimeler: Doxorubicin, Poly(HEMA/acrylamide/methyl methacrylate), Poly(Acrylamide/methyl methacrylate), Drug release, ADSORPTION
  • Erciyes Üniversitesi Adresli: Evet

Özet

Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate)(PAM) polymers were synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate) (PAM) composite hydrogels were prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, and methacrylamide, with the presence of N, N'-methylenebisacrylamide. The characterization of the polymer was performed by FTIR analysis. Swelling and drug absorption properties of the polymers were analyzed in distilled water. Polymers' toxic effects were investigated by XTT assay. It has been observed that the entire drug, which was added to the solution with 1 g of polymer, was absorbed for 3.5 h. The absorption of these polymers was found quite high. PHAM polymer showed >800% swelling and PAM polymer showed >600% at 600 min. PHAM polymer was less toxic than PAM polymer. These results, this new polymer is very suitable for the release of Doxorubicin drug.