Rubella-associated hemophagocytic syndrome in an infant

BAYKAN A., AKCAKUS M., Deniz K.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.27, no.8, pp.430-431, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 8
  • Publication Date: 2005
  • Doi Number: 10.1097/01.mph.0000177427.94164.df
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.430-431
  • Keywords: rubella, hemophagocytic syndrome, leukoerythrophagocytosis, infant
  • Erciyes University Affiliated: Yes

Abstract

Hemophagocytic syndrome (HPS) is a fulminant disorder characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes in the lymphoreticular tissues. The characteristic pathologic feature is reactive histiocytic hyperplasia with leukoerythrophagocytosis in a variety of organs. This disorder occurs most often in patients in whom the immune system is compromised and has been associated with a variety of infectious agents, including viruses, bacteria, mycobacteria, spirochetes, fungi, and parasites. The authors describe a 2.5-month-old girl with rubella-associated HPS, demonstrated by postmortem liver necropsy.