Nickel-based Inconel 625 is employed in critical applications because of its excellent properties. But the machinability of this material is very poor. In recent years, the use of minimum quantity lubrication has gained prominence to improve machining performance without increasing the oil. However, pure-MQL may be insufficient for machining of difficult-to-machine materials. This paper focused on the development of nano-MQL by adding ISBN nanoparticles compared to pure-MQL and dry machining in turning of Inconel 625. Tool life, surface roughness, tool wear and tool-chip interface temperature were analyzed. Wear mechanisms were evaluated by SEM photographs and EDX analysis. The results showed that; 0.5 vol% hBN nanofluid has produced promising results for low tool wear and roughness and high tool life.