Aspects of using N-acetylcysteine in aflatoxicosis and its evaluation regarding some lipid peroxidation parameters in rabbits


Eraslan G. , Çam Y. , Eren M. , Liman B. C. , Atalay O., Şeybek N.

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY, cilt.49, ss.243-247, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 49 Konu: 2
  • Basım Tarihi: 2005
  • Dergi Adı: BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY
  • Sayfa Sayıları: ss.243-247

Özet

In the study, 42 rabbits, 6 to 8 weeks of age, were divided into 6 groups. Groups 2, 3, and 4 were given, by a catheter directly into the stomach, aflatoxin (AF) (78.70% of AF B-1, 10.80% of AF B-2, 6.80% of AF G(1), 3.70% of AF G(2)) in a dose of 0.4 mg/kg/bw/d in dimethyl sulfoxide (DMSO), while groups 1, 5, and 6 were simultaneously given the same dose of DMSO with no AF. Twenty-four hours after AF was given, N-acetylcysteine (NAC) was administered intramuscularly at a dose of 250 mg/kg/bw/d to groups 3 and 5 and at a dose of 500 mg/kg/bw/d to groups 4 and 6 for 6 d. At the beginning of the trial (day 0) and on days 1, 4, and 7 following the administration of AF, blood was taken into heparinized tubes, and malondialdehyde level and superoxide dismutase and catalase activities were examined. It was found that AF caused oxidative damage and NAC was effective, at least partly, in the prevention of this damage. Consequently, it was obvious that NAC can be used as ameliorative agent in combination with other drugs in order to alleviate the adverse effects of AF action.