Comparison of serum NO, TNF-alpha, IL-1 beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus

Doganay S., Evereklioglu C., Er H., Turkoz Y., Sevinc A., Mehmet N., ...More

EYE, vol.16, no.2, pp.163-170, 2002 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1038/sj.eye.6700095
  • Journal Name: EYE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.163-170
  • Erciyes University Affiliated: Yes

Abstract

Background Vitreal interleukin (IL)-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) levels have previously been determined in patients with proliferative diabetic retinopathy (PDR). However, at present there is no cohort study linking serum levels of NO and many inflammatory cytokines such as TNF-alpha, IL-1beta, soluble IL-2 receptor (sIL-2R), IL-6 and IL-8 to the grade of the microvascular complications.