The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model


Akyildiz H. Y. , Akcan A., Sozuer E., Kucuk C., Yilmaz N., DENİZ K.

SURGERY, cilt.144, ss.404-409, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 144 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.surg.2008.04.012
  • Dergi Adı: SURGERY
  • Sayfa Sayısı: ss.404-409

Özet

Background. Chemokines are proinflammatory proteins that participate in immune and inflammatory responses through chemoattraction and leukocyte activation. The chemokine antagonist Met-RANTES (Regulated upon Activation Normal T cell Expressed and Secreted) has been shown to be efficacious in decreasing inflammation in several animal disease models. The purpose of this study was to investigate the effects of administration of Met-RANTES on intra-abdominal adhesion formation after abdominal operation.