The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model

Akyildiz H. Y., Akcan A., Sozuer E., Kucuk C., Yilmaz N., DENİZ K.

SURGERY, vol.144, no.3, pp.404-409, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.surg.2008.04.012
  • Journal Name: SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.404-409
  • Erciyes University Affiliated: Yes

Abstract

Background. Chemokines are proinflammatory proteins that participate in immune and inflammatory responses through chemoattraction and leukocyte activation. The chemokine antagonist Met-RANTES (Regulated upon Activation Normal T cell Expressed and Secreted) has been shown to be efficacious in decreasing inflammation in several animal disease models. The purpose of this study was to investigate the effects of administration of Met-RANTES on intra-abdominal adhesion formation after abdominal operation.