Diğer, ss.4-10, 2021
ABSTRACT
Objective: In this study, it was aimed to reveal a more
effective model depending on the dose and time by evaluating histopathological
properties and biochemical parameters, such as alanine aminotransferase (ALT),
aspartate aminotransferase (AST), albumin, triglyceride, cholesterol in carbon
tetrachloride and thioacetamide (CCl4 and TAA) models.
Method: Rats were divided into three groups for each model and
intraperitoneally (i.p.) injected with CCl4 (0.5 ml/kg, 1.0 ml/kg,
2.0 ml/kg) and TAA (100 mg/kg, 200 mg/kg, 300 mg/kg) for 4, 6 and 8 weeks,
three times weekly, respectively.
Results: In the biochemical investigation, ALT and AST values
in the only 0,5 ml CCL4 of groups for 6 and 8 weeks and
were found to have significant differences compared to the control groups (p <0.05), while the other biochemicals parameters values did
not reveal significant difference in the groups (p >0.05). According to the
results of the histopathology in the liver tissues, both the control groups
showed a normal histological feature. The hepatofibrotic alterations were
remarkable in the CCl4 and TAA models fibrosis depending on the
increasing dose and time in all of the groups.
Conclusion: Our results showed that the dose and time were reached
up to until the cirrhosis for eighth week. These results would be a helpful
reference for hepatofibrotic studies.
Keywords: TAA, CCl4, Liver, Fibrosis