The association of serum total sialic acid/total protein ratio with diabetic parameters in young type 1 diabetic patients

Kurtoglu S., Atabek M. E., Muhtaroğlu S., Keskin M.

ACTA DIABETOLOGICA, cilt.43, sa.1, ss.1-5, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s00592-006-0202-x
  • Dergi Adı: ACTA DIABETOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-5
  • Anahtar Kelimeler: serum total sialic acid, serum total sialic acid/total protein ratio, young type 1 diabetic patients, CORONARY HEART-DISEASE, ACID CONCENTRATION, RISK-FACTOR, RETINOPATHY, HYPERTRIGLYCERIDEMIA, PLASMA, NIDDM, IDDM
  • Erciyes Üniversitesi Adresli: Evet

Özet

Sialic acid is a terminal component of the non-reducing end of carbohydrate chains of glycoproteins and glycolipids. The purpose of this study was to estimate serum total sialic acid (TSA) concentrations and serum TSA/serum total protein (TP) ratios in young type 1 diabetic subjects and to investigate their association with diabetes-related parameters in that population. Twentyfour young type 1 diabetic patients and 20 healthy controls were enrolled in this study. Serum TSA and serum TSA/TP ratio were measured in both groups. Moreover, we looked for correlation among serum TSA, serum TSA/TP ratio and clinically relevant parameters such as urinary albumin excretion, blood pressure, diabetes duration, HbA1c, daily insulin dose, serum lipids and magnesium in type 1 diabetic patients. Serum TSA concentrations and serum TSA/TP ratio showed no statistical difference between patients and controls (p > 0.05). While serum TSA concentrations only correlated with urinary albumin excretion (r=0.44, p=0.028), serum TSA/TP ratio correlated with diastolic blood pressure (r=0.48, p=0.015), diabetes duration (r=0.46, p=0.022) and urinary albumin excretion (r=0.53, p=0.007) in the diabetic subjects. We concluded that serum TSA/TP ratio might be a better indicator than serum TSA as an index of diabetic complications.