Akademik Veri Yönetim Sistemi
Journal of Electroanalytical Chemistry, cilt.1007, 2026 (SCI-Expanded, Scopus)
The simultaneous determination of cabotegravir (CABO) and dopamine (DOP) is clinically relevant, as monitoring an antiviral drug alongside a key neurotransmitter can offer valuable insight into therapeutic response, drug interactions, and potential neurochemical effects. This work reports the first electrochemical sensor developed for the simultaneous determination of CABO and DOP. A high-performance electrochemical sensor was developed using a novel SrCr-LDH@MWCNTs nanocomposite as an efficient electrode modifier. The synergistic combination of SrCr-LDH and MWCNTs enhanced electrical conductivity, electroactive surface area, and charge-transfer capability. Electrochemical characterization using cyclic voltammetry and electrochemical impedance spectroscopy demonstrated significantly improved charge-transfer kinetics compared to the bare glassy carbon electrode. Under optimized differential pulse voltammetry conditions, the SrCr-LDH@MWCNTs/GCE sensor enabled clear and simultaneous oxidation of DOP and CABO in Britton–Robinson buffer (pH 2.0). The platform exhibited wide linear ranges (1.0–90 μM for DOP and 0.1–11 μM for CABO) and low detection limits (0.08 μM and 0.015 μM, respectively). The sensor was successfully applied to pharmaceutical samples and biological matrices, achieving recoveries of 98.95–101.96% with RSD values below 3%. These results highlight the SrCr-LDH@MWCNTs-modified electrode as a sensitive, stable, and reliable platform for simultaneous CABO and DOP monitoring in clinical and pharmaceutical settings.