Akademik Veri Yönetim Sistemi
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.31, sa.6, ss.781-789, 2025 (SCI-Expanded, Scopus, TRDizin)
Respiratory system infections are one of the most critical problems that can cause
serious economic losses and mortality in cattle breeding. Our study aimed to investigate
the significance of endocan levels, which have been shown to yield successful outcomes
in predicting prognosis in various respiratory disorders in human medicine, as a reliable
prognostic biomarker in calves affected by enzootic pneumonia (EP). The study also
examined the efficacy of lactate levels and a modified respiratory scoring system (MSS)
in predicting death, alongside endocan levels. Calves with EP (n=53) and healthy calves
(n=27) were included in the study and only single blood sample was collected from each
calf in the study. Blood samples were taken from the EP group prior to treatment. Our
investigation revealed that endocan levels were considerably lower in calves with EP
compared to healthy calves (P<0.001). Our study assessed the diagnostic and prognostic
significance of endocan and lactate levels in calves with EP using ROC analysis. The
cut-off values for endocan and lactate employed in illness prediction were <70.41
(AUC=0.734, P=0.001) and >2.55 (AUC=0.842, P<0.001), respectively. Cut-off values for
mortality prediction were >64.96 for endocan (AUC=0.657, P=0.052), >3.90 for lactate
(AUC=0.940, P<0.001), and >7.5 for MSS (AUC=0.848, P<0.001). We concluded that
endocan had limited diagnostic utility. However, the modified scoring system showed
considerable efficacy in predicting mortality. Furthermore, lactate levels have been
shown to exhibit superior accuracy and clinical value for both diagnosis and prognosis.