Efficacy of mepolizumab treatment in oral corticosteroid-dependent severe eosinophilic asthma patients with chronic rhinosinusitis with nasal polyps: single center, real life study

YILMAZ İ., TÜRK M., NAZİK BAHÇECİOĞLU S., TUTAR N., GÜLMEZ İ.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.2, ss.433-441, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-1912-62
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.433-441
  • Anahtar Kelimeler: Severe asthma, eosinophilic asthma, chronic rhinosinusitis, nasal polyps, mepolizumab, anti-IL5, INFLAMMATION, MANAGEMENT, PHENOTYPES, DISEASE, COUNT, CELLS, DREAM
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background/aim: Oral corticosteroid (OCS)-dependent severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps (SEA-CRSwNP) would be a suitable phenotype for mepolizumab treatment. This study evaluated the short-term efficacy of mepolizumab treatment in OCS-dependent SEA-CRSwNP.