Efficacy of mepolizumab treatment in oral corticosteroid-dependent severe eosinophilic asthma patients with chronic rhinosinusitis with nasal polyps: single center, real life study

YILMAZ İ. , TÜRK M. , NAZİK BAHÇECİOĞLU S. , TUTAR N. , GÜLMEZ İ.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.2, pp.433-441, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-1912-62
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.433-441
  • Keywords: Severe asthma, eosinophilic asthma, chronic rhinosinusitis, nasal polyps, mepolizumab, anti-IL5, INFLAMMATION, MANAGEMENT, PHENOTYPES, DISEASE, COUNT, CELLS, DREAM

Abstract

Background/aim: Oral corticosteroid (OCS)-dependent severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps (SEA-CRSwNP) would be a suitable phenotype for mepolizumab treatment. This study evaluated the short-term efficacy of mepolizumab treatment in OCS-dependent SEA-CRSwNP.