Reactions of aminoguanidine derivatives with acetylenedicarboxylate derivatives

Tez Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Erciyes Üniversitesi, Fen Bilimleri Enstitüsü, Kimya, Türkiye

Tez Danışmanı: Prof. Dr. Zülbiye Kökbudak

Tezin Onay Tarihi: 2016

Tezin Dili: İngilizce

Özet:

Aminoguanidine, also known as pimagedin, is a drug under investigation for the treatment diabetic nephropathy. Because of this feature, synthesis of aminoguanidin derivatives as a prospective drug for diabetic nephropathy is gained more importance. In this study, some aminoguanidine derivatives have been synthesized by an environmentally friendly method. Then, aminoguanidine derivatives have been reacted to dimethyl acetylenedicarboxylate (DMAD) and diethyl acetylenedicarboxylate (DEAD) in order to synthesize new imidazolidine derivatives which are considered as biologically active molecules. And, structures of molecules are determined by using 1HNMR, 13C-MNR, IR Spectroscopy, and elemental analysis.