Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients

ÖZKAN M., GÜNAY N., ŞENER E. F., Karcioglu O., Tahtasakal R., Dal F., ...Daha Fazla

JOURNAL OF GENE MEDICINE, cilt.23, sa.4, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/jgm.3323
  • Dergi Adı: JOURNAL OF GENE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Anahtar Kelimeler: endothelial nitric oxide synthase, polymorphism, sepsis, susceptibility, tumor necrosis factor, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE SYNTHASE, FACTOR-ALPHA PROMOTER, CORONARY-ARTERY-DISEASE, SEPTIC SHOCK, GLU298ASP POLYMORPHISM, HEMODIALYSIS-PATIENTS, ORGAN DYSFUNCTION, CLINICAL-COURSE, GREATER-THAN
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.