NUCLEIC ACID-FUNCTIONALIZED NANOMATERIALS


ÖÇSOY I. , Yasun E., Ocsoy M. A. , Tan W.

Nano LIFE, vol.3, no.1, pp.1-10, 2013 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Review
  • Volume: 3 Issue: 1
  • Publication Date: 2013
  • Title of Journal : Nano LIFE
  • Page Numbers: pp.1-10

Abstract

Nucleic acid (NA)-functionalized nanomaterials (NMs) have received considerable attention in
recent years. The use of nucleic acid (DNA/RNA) for surface functionalization of NMs o®ers the
ability to directly address desired targets and coat NMs with biocompatible polymers, such as
poly [(ethylene)] glycol (PEG) and polyacrylamide (PA), enhancing the utility of these complexes
in biomedicine. In particular, the target-speci¯c recognition capacity of surface-functionalized
NMs has opened up new avenues for disease diagnosis and therapy. This review focuses on the
biological applications of a special type of nucleic acid, termed aptamer, conjugated with a variety
of NMs for a wide spectrum of applications in nanobiomedicine