The Expression of IL-1β gene In Response to Mannheimia haemolytica Bacteria in Sheep Alveolar Macrophages in vitro

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Sohel M. M. H.

11th INTERNATIONAL ANIMAL SCIENCE CONGRESS, Kayseri, Türkiye, 20 - 22 Ekim 2019, cilt.1, ss.159-160

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 1
  • Basıldığı Şehir: Kayseri
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.159-160
  • Erciyes Üniversitesi Adresli: Evet

Özet

Small ruminants, particularly sheep, are suffering from many respiratory diseases. Among the causative agents of respiratory diseases, the most important microorganisms are Mannheimia haemolytica. In the case of a most severe form of infection which is commonly known as the severe fibrinous pleuropneumonia characterized by fibrin deposition and merging, intra-alveolar hemorrhage, forceful leukocyte infiltration in alveoli of the lungs. Being a Gram-negative bacterium, Mannheimia haemolytica is causing respiratory diseases in animals and pneumonia which is the must dangers diseases that make a great economic loss. The sheep immune system is responsible for the detection, capturing and elimination of foreign bodies including bacteria. However, there are no substantial studies explaining the molecular mechanism of respiratory diseases and immune system response in sheep lung. Therefore, this study was conducted to investigate the expression pattern of IL-1β, one of the important genes in immune system, to understand the molecular mechanism underlying in M. haemolytica induced infection in sheep lung.