Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86

CANPOLAT M., PER H., GÜMÜŞ H., Yikilmaz A., ÜNAL E., PATIROĞLU T., ...More

CHILDS NERVOUS SYSTEM, vol.30, no.2, pp.227-240, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1007/s00381-013-2185-6
  • Journal Name: CHILDS NERVOUS SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.227-240
  • Keywords: Children, Epilepsy, Rapamycin, Tuberous sclerosis complex, GIANT-CELL ASTROCYTOMA, MAMMALIAN TARGET, SIGNALING PATHWAY, PHARMACOLOGICAL INHIBITION, CONSENSUS CONFERENCE, INFANTILE SPASMS, NATURAL-HISTORY, MTOR PATHWAY, MOUSE MODEL, VIGABATRIN
  • Erciyes University Affiliated: Yes

Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder characterized by the formation of hamartomas in various organ systems. We would like share our experience from 86 patients and the results of rapamycin treatment in seven children with TSC.