Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds


Erdem Buyukkiraz M., Kesmen Z.

JOURNAL OF APPLIED MICROBIOLOGY, vol.132, no.3, pp.1573-1596, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 132 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1111/jam.15314
  • Journal Name: JOURNAL OF APPLIED MICROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, DIALNET
  • Page Numbers: pp.1573-1596
  • Keywords: antibacterial, antimicrobial peptides, antiviral, applications of AMPs, mechanism of action, origins of AMPs, PLANT-PATHOGENIC BACTERIA, CYCLIC CYSTINE LADDER, ANTIBACTERIAL PEPTIDE, MEMBRANE INTERACTIONS, TRANSGENIC TOBACCO, PICHIA-PASTORIS, PHYTOPATHOGENIC BACTERIA, DIETARY SUPPLEMENTATION, ENHANCES RESISTANCE, INHIBITORY-ACTIVITY
  • Erciyes University Affiliated: Yes

Abstract

Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against microorganisms. In the last decades, AMPs have become powerful alternative agents that have met the need for novel anti-infectives to overcome increasing antibiotic resistance problems. Moreover, recent epidemics and pandemics are increasing the popularity of AMPs, due to the urgent necessity for effective antimicrobial agents in combating the new emergence of microbial diseases. AMPs inhibit a wide range of microorganisms through diverse and special mechanisms by targeting mainly cell membranes or specific intracellular components. In addition to extraction from natural sources, AMPs are produced in various hosts using recombinant methods. More recently, the synthetic analogues of AMPs, designed with some modifications, are predicted to overcome the limitations of stability, toxicity and activity associated with natural AMPs. AMPs have potential applications as antimicrobial agents in food, agriculture, environment, animal husbandry and pharmaceutical industries. In this review, we have provided an overview of the structure, classification and mechanism of action of AMPs, as well as discussed opportunities for their current and potential applications.