Increased endothelial microparticles in obese and overweight children

Gunduz Z., Dursun I., Tulpar S., Bastug F., BAYKAN A., Yikilmaz A., ...Daha Fazla

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.25, ss.1111-1117, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1515/jpem-2012-0194
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1111-1117
  • Anahtar Kelimeler: atherosclerosis, childhood obesity, endothelial microparticles, inflammation, LEFT-VENTRICULAR HYPERTROPHY, CIRCULATING MICROPARTICLES, NONHYPERTENSIVE CHILDREN, DYSFUNCTION, CELLS, ATHEROSCLEROSIS, HYPERTENSION, ACTIVATION, MARKER, BLOOD
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: Obesity in children increases the risk of atherosclerosis. Endothelial dysfunction is an important factor in the pathogenesis of atherosclerosis, and endothelial microparticles (EMPs) are considered as markers of endothelial dysfunction. In this study, we aimed to evaluate circulating EMPs in obese and overweight children and to disclose the measure of obesity with the strongest relation with circulating microparticles and carotid atherosclerosis. Methods: This prospective study included 55 obese and overweight children and 23 healthy controls. Insulin resistance was studied. Both in vivo and in vitro human umbilical vein endothelial cell evaluations were used for the study. Circulating EMPs (CD144 and CD146) were measured by flow cytometry. The carotid artery intima-media thickness (cIMT) and left ventricular mass index (LVMI) were measured using ultrasound and echocardiography, respectively. Study groups were compared for anthropometric measurement, insulin resistance, circulating EMP, cIMT, and LVMI. The relationship among overweight, obesity, and circulating EMPs were investigated.