Anti-inflammatory activity of 2,5-dihydroxycyclohepta-2,4,6-trienone in rats


KOÇ F. , ÇADIRCI E., ALBAYRAK A., HALICI Z., HACIMÜFTÜOĞLU A., Suleyman H.

MEDICINAL CHEMISTRY RESEARCH, vol.19, no.1, pp.84-93, 2010 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1007/s00044-009-9174-z
  • Title of Journal : MEDICINAL CHEMISTRY RESEARCH
  • Page Numbers: pp.84-93
  • Keywords: Hyaluronidase, Tropolone, Anti-inflammatory, Capillary permeability, Toxicity, SELECTIVE INHIBITOR, BIOLOGICAL-ACTIVITY, BETA-THUJAPLICIN, RUMEX-PATIENTIA, AQUEOUS EXTRACT, DERIVATIVES, HINOKITIOL, TROPOLONE, 4-ACETYLTROPOLONE, CARRAGEENAN

Abstract

In this study, the anti-inflammatory effects of a tropolone derivative, 2,5-dihydroxycyclohepta-2,4,6-trienone (AD-4), were investigated. The anti-inflammatory potency of AD-4 was compared with that of indomethacin in carrageenan-induced inflammation models in rats. The effect on vascular permeability was also determined by hyaluronidase-induced capillary permeability. AD-4 decreased carrageenan-induced paw edema at doses of 3.62 x 10(2), 7.24 x 10(2), and 14.48 x 10(2) mu mol/kg by 45% (p < 0.001), 79% (p < 0.001), and 83% (p < 0.001), respectively, compared with the value of 49% (p < 0.001) for indomethacin (69.8 mu mol/kg). Additionally, AD-4 decreased hyaluronidase-induced capillary permeability significantly. In conclusion, AD-4 was determined to have anti-inflammatory effects with lower toxicity than indomethacin. Anti-inflammatory effect of AD-4 may be related to its effects on vascular permeability.