Cytotoxic Activity Evaluation of Three New Metal Complexes

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Atıf İçin Kopyala

Aslan H. G., Akkoç S., Kökbudak Z.

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.14, sa.1, ss.306-313, 2021 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 14 Sayı: 1
• Basım Tarihi: 2021
• Doi Numarası: 10.18185/erzifbed.875774
• Dergi Adı: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
• Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.306-313
• Erciyes Üniversitesi Adresli: Evet

Özet

Abstract Salicylaldehyde and 1-amino-5-(4-methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one were used for preparing a Schiff base, which is 1-(2-hydroxybenzylideneamino)-5-(4-methylbenzoyl)-4-p-tolylpyrimidin-2(1H)-one (S1). Three new complexes (Ag(I), Pd(II), and Pt(II)) were synthesized from this chelate ligand (S1). The Ag(I) complex was screened against the human colon cancer cell line, and the silver complex was found to have more cytotoxic activity than a standard drug used.