Argyrophilic nucleolar organizing region associated protein synthesis in hair root cells of humans at different developmental stages and sex

Eroz R., YILMAZ S., CÜCER N.

BIOTECHNIC & HISTOCHEMISTRY, cilt.88, sa.5, ss.267-271, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/10520295.2013.769632
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.267-271
  • Anahtar Kelimeler: AgNORs, developmental stage, hair root, rRNA, RNA-GENE ACTIVITY, METAPHASE CHROMOSOMES, STEM-CELLS, AGE, LYMPHOCYTES, CHROMATIN, FOLLICLE
  • Erciyes Üniversitesi Adresli: Evet

Özet

Argyrophilic nucleolar organizing region (AgNORs) associated proteins are important for cell proliferation and various diseases. We investigated AgNOR protein synthesis in hair root cells of males and females at different ages using two-dimensional image analysis. Experiments were performed on 58 healthy male and 24 healthy female volunteers in three groups according to age and sex. Hair root cells obtained from hair follicles were stained with silver. Total AgNOR number/total nuclear number (TAN/TNN) and total AgNOR area/nuclear area (TAA/NA) for each nucleus were analyzed. The only significant difference was observed in TAA/NA values for males and females from 6 to 12 years old. We suggest that the difference is due to high NOR activity caused by increased growth hormone production in hair root cells.