The purpose of this study was to determinate the effects of 12 weeks aerobic exercise on waist to hip ratio, blood pressure, heart rates, blood serum lipids and lipoproteins on sedentary females. Twenty three sedentary women with an average age of 44.63 years, height of 159.27 cm and weight of 71.5 kg have been selected and put through an aerobic exercise programmer one hour a day for three days a week. Exercises in each training session were arranged in such a way as to make each woman’s heart rate to reach a level of 130-140 a minute. The waist and hip circumferences were measured using a measuring tape. BMI and waist hip ratio were calculated by standard formulas. Triglyceride (TG), Total Cholesterol (TC), High density lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) levels were determined by Hitachi 717 auto analyzer. Analysis was performed on SPSS 21 version. Paired-t tests were done statistical analysis. Body Weight found before 3 months aerobic exercise 71,5 kg and after 64.3 kg. At the end of the three months exercise program, a decrease of 10.07% in body weight, 13.13% in systolic, 3.35% in diastolic, 13.9% in cholesterol, 25.3% in Triglyceride, and 22.07% in LDL-C have been registered. However, there were increases of 16.34% in HDL-C. The effects of aerobic exercise is on Triglyceride, HDL-C, LDL-C and total cholesterol since (p<0.01). At the end of the three months exercise program, a decrease 11.74% hip circumference and 3.46% waist circumference. Waist to hip ratio found before 3 months aerobic exercise 0.86cm and after 0.79 cm. The effects of aerobic exercise is on Body weight, Systolic blood pressure, Heart rate, hip and waist circumference since (p<0.05; p<0.01). In this study, aerobic exercise was effective in female with initially high total cholesterol, triglyceride, and LDL-C levels. At end of the activity 12 weeks aerobic exercises, decrease effects of waist to hip ratio, blood pressure, heart beats and blood parameters and cardiovascular system in middle-aged sedentary females.