Advances in biomedical applications of self-healing hydrogels


Rammal H., GhavamiNejad A., ERDEM A., Mbeleck R., Nematollahi M., Emir Diltemiz S., ...Daha Fazla

MATERIALS CHEMISTRY FRONTIERS, cilt.5, ss.4368-4400, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1039/d0qm01099e
  • Dergi Adı: MATERIALS CHEMISTRY FRONTIERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4368-4400
  • Erciyes Üniversitesi Adresli: Evet

Özet

Hydrogels are important biomaterials that have several applications in drug and cell delivery, tissue engineering, three-dimensional (3D) printing and more recently, in sensing and actuating applications. With the advent of self-healing hydrogels, it is becoming possible to have smarter materials with sustainable mechanical properties under stress and also added functionalities. The mechanisms responsible for the self-healing behavior of these materials are related to their internal structure and processes triggered by damage they may sustain. These mechanisms rely on either chemical bonding or physical interactions of the structural components of hydrogels, or on both. Many self-healing hydrogels have been developed and tested in vitro and in animals. However, there are still challenges, especially with healing characteristics that need to be addressed and investigated in animal experiments before their clinical applications can be initiated, for which a multidisciplinary approach is required. In the current paper, various biomedical applications of self-healing hydrogels are discussed in detail, highlighting current challenges and future prospects.