Clinical and microbiological evaluation of patients infected with “Achromobacter species”. A retrospective experience of 10 years

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Sağıroğlu P., Türe Yüce Z., Eren E., Atalay M. A.

33rd International Congress of Antimicrobial Chemotherapy (ICC):, İstanbul, Türkiye, 3 Kasım - 06 Aralık 2024, cilt.39, ss.46, (Özet Bildiri)

Özet

AIM/BACKGROUND

""Achromobacter species"" are aerobic, motile, non-fermentative Gram-negative bacilli that most often causes healthcare-associated infections. This study aimed to evaluate the characteristics of patients with ""Achromobacter spp."" infections, over ten years in a tertiary hospital.

METHODS

Demographic data, co-morbidities, laboratory findings, and treatments of the patients were evaluated retrospectively. Antimicrobial susceptibility results of the isolates were determined by disk diffusion and gradient strip test.

RESULTS

A total of 154 patients and their clinical isolates were included in the study. The median age was 54, and 68% were male. Among the patients, 107 had at least a chronic condition, and 61 (or 39%) had any form of immunosuppression. The majority of Achromobacter species (46%), which were isolated from surgical clinic samples, came from abscess and wound samples (43%). A polymicrobial infection was seen in 50 individuals, and 18 patients (12%) died within 28 days (Table). The rate of trauma was higher (26 vs. 8%; p = 0.002) and the rate of chronic disease was lower (58% vs. 75%; p = 0.032) in patients with polymicrobial infection. Patients with polymicrobial infections had a greater rate of abscess samples (68% vs. 36%; p<0.001). Patients with polymicrobial infection had a lower 28-day mortality rate (4% vs. 18%; p=0.037) (Table). Quinolones and cephalosporins had higher resistance rates (Figure).

CONCLUSIONS

""Achromobacter spp."" are isolated from immunocompromised individuals at a high frequency, but they can also be one of the polymicrobial agents, particularly from wound or abscess samples obtained from surgical clinics.

AIM/BACKGROUND

""Achromobacter species"" are aerobic, motile, non-fermentative Gram-negative bacilli that most often causes healthcare-associated infections. This study aimed to evaluate the characteristics of patients with ""Achromobacter spp."" infections, over ten years in a tertiary hospital.

METHODS

Demographic data, co-morbidities, laboratory findings, and treatments of the patients were evaluated retrospectively. Antimicrobial susceptibility results of the isolates were determined by disk diffusion and gradient strip test.

RESULTS

A total of 154 patients and their clinical isolates were included in the study. The median age was 54, and 68% were male. Among the patients, 107 had at least a chronic condition, and 61 (or 39%) had any form of immunosuppression. The majority of Achromobacter species (46%), which were isolated from surgical clinic samples, came from abscess and wound samples (43%). A polymicrobial infection was seen in 50 individuals, and 18 patients (12%) died within 28 days (Table). The rate of trauma was higher (26 vs. 8%; p = 0.002) and the rate of chronic disease was lower (58% vs. 75%; p = 0.032) in patients with polymicrobial infection. Patients with polymicrobial infections had a greater rate of abscess samples (68% vs. 36%; p<0.001). Patients with polymicrobial infection had a lower 28-day mortality rate (4% vs. 18%; p=0.037) (Table). Quinolones and cephalosporins had higher resistance rates (Figure).

CONCLUSIONS

""Achromobacter spp."" are isolated from immunocompromised individuals at a high frequency, but they can also be one of the polymicrobial agents, particularly from wound or abscess samples obtained from surgical clinics.