Investigation of double carbapenem efficiency in experimental sepsis of colistin resistant Klebsiella pneumoniae


KOŞAR İ., DİNÇ G., EREN E., AYKEMAT Y., KILIÇ M., KILIÇ H., ...More

Northern Clinics Of Istanbul, vol.8, pp.113-118, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2021
  • Doi Number: 10.14744/nci.2020.14238
  • Journal Name: Northern Clinics Of Istanbul
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.113-118
  • Keywords: Coastal resistance, experimental sepsis, Klebsiella pneumoniae, IN-VITRO ACTIVITY, BLOOD-STREAM INFECTIONS, MOLECULAR EPIDEMIOLOGY, COMBINATION, MEROPENEM, TIGECYCLINE, ERTAPENEM
  • Erciyes University Affiliated: Yes

Abstract

OBJECTIVE: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a "last resort" antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.