Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion

Bostanci M. E., HEPOKUR C., Caner A., Mollaoglu M. C., KARADAYI K.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.47, no.5, pp.633-639, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1515/tjb-2021-0244
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals
  • Page Numbers: pp.633-639
  • Keywords: clinoptilolite, ischemia-reperfusion, ischemic small intestines, RT-qPCR, TNF-alpha, ENDOTHELIAL DYSFUNCTION, OXIDATIVE STRESS, LUNG INJURY, ISCHEMIA/REPERFUSION, BARRIER, ACTIVATION, ZEOLITE, DAMAGE, IL-6, TNF
  • Erciyes University Affiliated: Yes


Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia, the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. Clinoptilolite is one of the most abundant natural zeolites, and it is used for its ion exchange and adsorbent properties. Clinoptilolite has been reported to have an immune-enhancing, anti-carcinogenic, and antioxidant effect in-vitro/in-vivo studies. Clinoptilolite's histological and biochemical effects on ischemic small intestines.