Protective effects of spironolactone against anthracycline-induced cardiomyopathy
EUROPEAN JOURNAL OF HEART FAILURE, cilt.17, sa.1, ss.81-89, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.1002/ejhf.196
- Dergi Adı: EUROPEAN JOURNAL OF HEART FAILURE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.81-89
- Anahtar Kelimeler: Spironolactone, Anthracycline, Cardiomyopathy
- Erciyes Üniversitesi Adresli: Evet
Özet
AimsThe protective effect of beta-blockers, ACE inhibitors, and ARBs on anthracycline cardiotoxicity has already been demonstrated, but the effect of aldosterone antagonism, which inhibits the last step of the renin-angiotensin-aldosterone system (RAAS), was questioned. This study sought to investigate whether spironolactone protects the heart against anthracycline-induced cardiotoxicity.