Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions


Paskeh M. D. A. , Asadi A., Mirzaei S., Hashemi M., Entezari M., Raesi R., ...More

CELLULAR SIGNALLING, vol.94, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94
  • Publication Date: 2022
  • Doi Number: 10.1016/j.cellsig.2022.110323
  • Journal Name: CELLULAR SIGNALLING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Ischemia, reperfusion injury, AMPK, Oxidative stress, Apoptosis, Autophagy, Cell death, ISCHEMIA-REPERFUSION INJURY, MYOCARDIAL ISCHEMIA/REPERFUSION INJURY, SEPSIS CAMPAIGN GUIDELINES, ACTIVATED PROTEIN-KINASE, ACUTE LUNG INJURY, INTESTINAL ISCHEMIA, INTERNATIONAL GUIDELINES, OXIDATIVE STRESS, LIVER ISCHEMIA, COLD ISCHEMIA
  • Erciyes University Affiliated: Yes

Abstract

Ischemia is a pathological process in which blood supply to a particular organ is temporarily interrupted resulting in disturbed biological function and homeostasis of local tissues. Following ischemia, reperfusion and reoxygenation may occur which further worsens oxidative stress-mediated damage in cells and tissues. The combined processes are referred to as ischemia/reperfusion (I/R) injury. Immediate management and treatment of I/R is of utmost importance for preventing irreversible and extensive cellular damage. Apoptosis, inflammation and oxidative stress are the most validated pathologies associated with I/R. AMP-activated protein kinase (AMPK) modulates energy metabolism in cells and its activation occurs in response to elevated AMP and ADP levels. Aberrant levels of AMPK are noted in various pathological settings such as diabetes mellitus, cancer and neurological diseases. This review emphasizes AMPK signaling, its related molecular pathways and therapeutic utility during I/R. Activation of AMPK through phosphorylation prevents apoptosis and reduces oxidative stress and inflammation upon I/R. Inducing AMPK signaling normalizes mitochondrial function to inhibit cell death. Autophagy as a cytoprotective mechanism undergoes activation by AMPK/mTOR and AMPK/ULK1 pathways.