DNA Cleavage Properties, Antimicrobial and Cytotoxic Activity and 4D-QSAR Analysis of Some Pyrazole Derivatives

Köprü S., Kup F. O., Sabanci N., Çadır M., Bulut D. C., Duman F., ...Daha Fazla

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, ss.904-918, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570180815666180926104319
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.904-918
  • Anahtar Kelimeler: DNA cleavage, antimicrobial activity, cytotoxic activity, EC-GA method, 4D-QSAR, pyrazole, ELECTRON-CONFORMATIONAL METHOD, PHARMACOPHORE IDENTIFICATION, BIOACTIVITY PREDICTION, ACID-CHLORIDES, BINDING, EVALUATE, 3D-QSAR, MODELS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: An extensive study of 19 pyrazole derivatives were carried out based on the evaluation of DNA cleavage properties, antimicrobial and cytotoxic activities and 4D-QSAR analysis including pharmacophore modelling and bioactivity prediction by the Electron Conformational-Genetic Algorithm (EC-GA) method.