The number and activity of CD3(+)TCR V alpha 7.2(+)CD161(+) cells are increased in children with acute rheumatic fever

Ozkaya M., Baykan A., Cakir M., Vural C., Sunkak S., Unal E., ...Daha Fazla

INTERNATIONAL JOURNAL OF CARDIOLOGY, cilt.333, ss.174-183, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 333
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.ijcard.2021.02.020
  • Dergi Adı: INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database
  • Sayfa Sayıları: ss.174-183
  • Anahtar Kelimeler: Acute rheumatic fever, ARF, Mucosal-associated invariant cell, MAIT, INVARIANT T-CELLS, HEART-DISEASE, MAIT CELLS, CYTOKINES, AUTOIMMUNITY, PATHOGENESIS, PROGRESSION, STATEMENT, CLONES, IL-17
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background: Acute rheumatic fever (ARF) is an autoimmune disease caused by group A beta-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MATT) cells are enriched at the mucosa and are present in the blood and may be activated by GAS.