This paper presents a novel method based on the artificial intelligence to redesign of morphing Unmanned Aerial Vehicle (UAV) for improvement of index consisting of directional stability and maximum lift/drag (L/D) ratio. In this study, Artificial Neural Network (ANN) based objective function is optimized with Artificial Bee Colony (ABC) algorithm. Firstly, the sweep angle is selected as input parameter and directional stability and maximum L/D ratio are selected as output parameters for ANN. ANN is trained with a small number of data obtained by the computational fluid dynamics method and the trained ANN is used for multiplying these data. Two ABC optimization algorithms with different objective functions are used to improve the index consisting of directional stability and maximum L/D ratio: While the first is used the adjustment of the ANN weights, the second is used the optimization of the ANN based objective function. Simulation results realized with limited data show that although directional stability and maximum L/D ratio have inverse relation, they are optimized equally and simultaneously. Thus, the artificial intelligence techniques provide fast and accurate determination of the optimal aerodynamic shape of UAV without time consuming and complexity caused by theoretical calculations.