The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

Demiroglu-Zergeroglu, A.; Basara-Cigerim, B.; KILIÇ, ESER; YANIKKAYA-DEMIREL, G.

doi:10.1155/2010/851589

The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

Atıf İçin Kopyala

Demiroglu-Zergeroglu A., Basara-Cigerim B., KILIÇ E., YANIKKAYA-DEMIREL G.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2010
Doi Numarası: 10.1155/2010/851589
Dergi Adı: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Erciyes Üniversitesi Adresli: Evet

Özet

Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more e. ective when compared with individual treatment of agents.