L-Carnitine ameliorates the liver by regulating alpha-SMA, iNOS, HSP90, HIF-1alpha, and RIP1 expressions of CCL4-toxic rats

KARABULUT D., AKİN A. T., ÜNSAL M., LEKESİZCAN A., ÖZYAZGAN T. M., Keti D. B., ...Daha Fazla

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.24, sa.2, ss.184-190, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.22038/ijbms.2020.47711.10990
  • Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Index Islamicus, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.184-190
  • Anahtar Kelimeler: Alpha-SMA, CCL4, HIF-1alpha, HSP90, iNOS, RIP1, NITRIC-OXIDE, N-ACETYLCYSTEINE, FIBROSIS, DAMAGE, ANTIOXIDANT, TOXICITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective(s): Carbon tetrachloride (CCL4) toxicity triggers fibrosis, activating various mechanisms within the cell. We aimed to create damage with CCL4 and investigate the effectiveness of L-carnitine on the mechanisms we identified.