A comparison of two different oral contraceptives in patients with severe primary dysmenorrhoea

Uysal G., Akkaya H., Cagli F., Tutus S., Tayyar A. T.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.38, no.6, pp.828-832, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1080/01443615.2017.1410533
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.828-832
  • Keywords: Primary dysmenorrhoea, pain, ethinylestradiol/drospirenone, oestradiol valerate, dienogest/visual analogue scale, resistance index, UTERINE BLOOD-FLOW, DOUBLE-BLIND, DIENOGEST, ENDOMETRIOSIS, MANAGEMENT, TRIAL
  • Erciyes University Affiliated: Yes


Pain relief of two different oral contraceptive pills (OCPs) in severe primary dysmenorrhoea (PD) was compared. Sixty-six nulliparous patients with severe PD requiring contraception were evaluated. Group 1 comprised 33 healthy controls. Patients with severe PD were divided into two groups. Patients in Group 2 were administered oestradiol valerate/dienogest and patients in Group 3 were administered ethinylestradiol/drospirenone. Doppler indices of both uterine arteries (left and right) including systolic/diastolicrates (S/D), pulsatility index (PI) and resistance index (RI) were measured, and a visual analogue scale (VAS) was applied to patients before treatment. VAS scores and Doppler indices were repeated after 3 months of OCP treatment and the changes in values were compared. The demographic and clinical characteristics of the patients were similar. The mean value of RI was significantly lower after therapy in Groups 2 and 3 in the right and left uterine arteries (p = .001 and p = .039, respectively).