Emergence of increased Pseudomonas aeruginosa infections during tigecycline use


23rd European Congress of Clinical Microbiology an Infectious Diseases, Germany, 1 - 04 April 2013, no.2105, pp.171

  • Publication Type: Conference Paper / Full Text
  • Country: Germany
  • Page Numbers: pp.171
  • Erciyes University Affiliated: Yes


Background: Tigecycline demonstrates a potent broad-spectrum in vitro antibacterial activity against clinically
important gram-positive and gram-negative aerobic bacteria and anaerobes, but with the exception of
intrinsically resistant Pseudomonas aeruginosa (PA). Aim of this study is to evaluate if the treatment with
tigecycline is a risk factor for PA infection. Materials and methods: We performed a retrospective and
observational study during 2008-2010. Patients with PA infection were compared patients with nosocomial
infection other than PA. Patients were analyzed according to receive tigecycline before PA infection and also
the following data: sex, age, underlying diseases, infections, invasive procedures. Statistical analysis was
performed using Chi-square test and multiple logistic regression models. Results: A total of 1167 patients with
any hospital infections included to the study. Of these infections 493 (42%) were ventilator associated
pneumonia (VAP), 187(16%) were urinary tract infections (UTI),145 (12,4%) were bacteremia, 143 (12,2%)
were surgical site infections, 59(5%) were skin &soft tissue infections, 47 (4 %) were other nosocomial
infections. 278 (23,8 %) of them were with PA infection compared to 889 (76,2 %) patient without PA
infections. One hundred twelve (34 %) of patients received tigecycline before PA infection documented found
to be significantly more frequent rather than nosocomial infections (p< 0,01). Mean age of patients with PA
infections was 52 (4-86). PA infections were significantly more common against young patients. Underlying
diseases (malignancies, burn, diabetes mellitus, and steroid use, and immunsupression, cardiac, hepatic and
renal failure) were similar between to groups. Tracheostomy, thoracic drainage catheter and external ventricular
drain were also found significant risk factors for PA infections. Conclusion: PA is a frequent cause of serious
infections among hospitalized patients associated with considerable morbidity and mortality. Tigecycline
represents a therapeutic option in treating multidrug-resistant Gram-negative