Detecting Neurodegeneration on Optic Nerve and Cornea in Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorder

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Tomris M. A., Tomris Ç., Yetkin M. F.

European Journal of Neurology 2023, Budapest, Hungary, 1 - 04 July 2023, vol.30, no.13515101, pp.828

  • Publication Type: Conference Paper / Summary Text
  • Volume: 30
  • Doi Number: 10.1111/ene.15951
  • City: Budapest
  • Country: Hungary
  • Page Numbers: pp.828
  • Erciyes University Affiliated: Yes

Abstract

“Detecting Neurodegeneration on Optic Nerve and Cornea in Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorder”.

INTRODUCTION

Multiple Sclerosis (MS) and NeuroMyelitis Optica Spectrum Disorder (NMO-SD) are neurological

diseases that could target the optic nerve. Optic neuritis-caused MS and NMO-SD are difficult to

differentiate solely on clinical grounds. This study aimed to compare peripapillary retinal nerve fiber

layer (pRNFL) thickness and subbasal corneal nerve plexus (SNP) in patients with MS, NMO-SD, and

control subjects(CS).

METHODS

Optical coherence tomography (pRNFL thickness measurement) and in-vivo corneal confocal

microscopy (Parameters: central nerve branch density(CNBD), central nerve fiber length (CNFL), and

central nerve fiber density(CNFD) ) were performed on all participants.

RESULTS

The NMO-SD group had significantly lower visual acuity compared to MS and CS , and MS group had

significantly lower visual acuity compared to the CS. The NMO-SD group had significantly lower

Ischiara color vision scores than the MS group and CS. However, there wasn’t significant difference

between the MS group and CS

The pRNFL thickness was more severely reduced in both MS and NMO-SD groups compared to CS .

The NMO-SD group had significantly lower pRNFL thickness in the central and inferior regions than

the MS group. IVCM’s parameters were significantly lower in both MS and NMO-SD groups compared

to CS. There wasn’t significant difference between MS and NMO-SD groups.

CONCLUSION

Our study shows that axonal damage in both optic nerve and corneal SNP in MS and NMO-SD groups.

Consistent with previous findings, NMO-SD leads to more pronounced pRNFL thinning and visual

function impairment than the MS group. However, IVCM's parameters didn't show a significant differ

between the MS and NMO-SD groups.