The effect of granulocyte macrophage-colony stimulating factor on bacterial translocation after administration of 5-fluorouracil in rats

KUCUK C., Ozkan M., Akgun H., MUHTAROGLU S., Sozuer E. M.

JOURNAL OF SURGICAL RESEARCH, cilt.128, sa.1, ss.15-20, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jss.2005.04.037
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15-20
  • Anahtar Kelimeler: GM-CSF, 5-FU, chemotherapy, bacterial translocation, TNF, IL-6, experimental, MESENTERIC LYMPH-NODES, COLORECTAL-CANCER, BARRIER FUNCTION, SEPSIS, MICE, IMMUNOSTIMULATION, CHEMOTHERAPY, PROTECTS, SURGERY, MODEL
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background. After surgical resection for colorectal carcinoma there is a high recurrence rate and, therefore, adjuvant chemotherapy may be useful in some patients. 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic agent in the management of patients with colorectal cancer. However, gastrointestinal injury induced by chemotherapeutic agents may result in bacterial translocation from the gut into the systemic circulation. Granulocyte macrophage-colony stimulating factor (GM-CSF) may be used to prevent this side effect by means of macrophage activity stimulation.