Investigation of the relationship between the inhibitory activity of glycolic acid oxidase (GAO) and its chemical structure: Electron-topological approach

Guzel Y.

JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, cilt.366, ss.131-137, 1996 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 366
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/0166-1280(96)04514-9
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.131-137
  • Anahtar Kelimeler: glycolic acid oxidase, enzyme inhibitor, structure-activity relationship, electronic structure, ODOR
  • Erciyes Üniversitesi Adresli: Evet

Özet

Rules for the occurrence of the inhibitory activity of glycolic acid oxidase are formulated and discussed in terms of the so-called electron-topological approach. It is shown that the molecular fragment responsible for this kind of activity possesses fixed electronic and geometrical characteristics caused by a definite spatial arrangement of an oxygen atom and a group of carbon atoms. A series of 85 compounds including 36 active and 49 inactive compounds was studied.