Tumour necrosis factor alpha, lipid peroxidation and NO center dot are increased and associated with decreased free-radical scavenging enzymes in patients with Weill-Marchesani syndrome

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Evereklioglu C., Turkoz Y., Calis M., Duygulu F., Karabulut A.

MEDIATORS OF INFLAMMATION, cilt.13, sa.3, ss.165-170, 2004 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/09511920410001713547
  • Dergi Adı: MEDIATORS OF INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.165-170
  • Erciyes Üniversitesi Adresli: Evet

Özet

AIM: Weill-Marchesani syndrome (WMS) is a rare systemic disorder with both autosomal recessive and dominant inheritances. Accumulation of reactive oxygen species such as O-2(.-), H2O2 and OH. causes lipid peroxidation (LPO), whereas antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSHPx)) mediate defence against oxidative stress. Excess tumour necrosis factor (TNF)-alpha and NO. react with O-2(.-) and cause further antioxidant depletion with an increase in mutation frequency by H2O2. This study investigated the levels of SOD, GSHPx, catalase (CAT), TNF-alpha, NO. and LPO in patients with WMS.