The Comparison of the Efficacy of five Proton Pomp Inhibitors by Using Symptom Indices and Quality of Life Questionnaires in Gastroesophageal Reflux Disease


4. Conference AGPFMSEE, Ljubljana, Slovenia, 4 - 07 June 2015, vol.1, no.1, pp.14

  • Publication Type: Conference Paper / Full Text
  • Volume: 1
  • City: Ljubljana
  • Country: Slovenia
  • Page Numbers: pp.14
  • Erciyes University Affiliated: Yes


Objective: Although some patients may prefer using a particular kind of proton pump inhibitor in gastroesophageal reflux disease (GERD), there are not many studies showing the difference in the efficacy of proton pump inhibitors. The aim of this study was to compare the efficacy of the five proton pump inhibitors; lansoprazole, esomeprazole, rabeprazole, pantoprazole and omeprazole.

Materials and Methods: Patients with GERD submitting to Family Medicine and Gastroenterology outpatient clinics were randomly allocated to five study groups, each consisting of 20 patients. In addition to the demographic data, the patients were asked to fill out four questionnaires. The patients were treated with one kind of proton pump inhibitor for four weeks, and the before and after treatment questionnaires were compared. This study was funded by the Scientific Research Council of Erciyes University (ERUBAP, Project No. TTU-2013-4839).


Results: In the GERD questionnaire, pantoprazole was more effective than omeprazole. In the reflux symptom index esomeprazole, pantoprazole and rabeprazole made statistically significant decrease. The scores were significantly decreased in all groups in the GERD health related quality of life scale, and the decrease was higher in pantoprazole group than in omeprazole group. In the work productivity and activity impairment questionnaire pantoprazole significantly decreased the effect of GERD in preventing the work productivity. Pantoprazole, rabeprazole and esomeprazole were better in reducing the preventive effect of GERD in daily activities than lanzoprazole and omeprazole.

Conclusion: All of the proton pump inhibitors are effective in the treatment of GERD, with various differences in their efficacies.