Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence, and small airways in patients with severe eosinophilic asthma
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.4, ss.1953-1959, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.3906/sag-2009-41
- Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1953-1959
- Anahtar Kelimeler: Mcpolizumab, severe cosinophilic asthma, small airways, pulmonary function, asthma control test, oral corticosteroids
- Erciyes Üniversitesi Adresli: Evet
Özet
Background: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. Objective: This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence and small airways in a real-life cohort of patients with SEA.