Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Erciyes Üniversitesi, Fen Fakültesi, Kimya, Türkiye
Tezin Onay Tarihi: 2018
Tezin Dili: İngilizce
Öğrenci: IHAB ADNAN SALMAN AL-JANABI
Asıl Danışman (Eş Danışmanlı Tezler İçin): Şaban Patat
Eş Danışman: EMİN SARIPINAR
Özet:
Dimethyl acetylenedicarboxylate (DMAD) has been used in numerous heterocyclic
arrangements and considered as an essential building in a natural union. In this work, a
short and productive one-pot reaction of 4-isothiazolidine-5-ylidene acetic acid
derivation is described. A green and effective technique for the a mixture of more up to
date 4-isothiazolidine-5-ylidene acetic acid derivation (IHB 1-16, yield 38-85%)N-
(arylideneamino)-N-(arylthiocarbamyl) guanidine (AGII 1- 22) with
diethylacetyylenedicarboxylate has been created in methanol by refluxing. We would
like to investigate the synthesis of thiazoline compounds from thiocarbamoyl guanidines
derivatives possessing N-H groups and S=C bond which react with DMAD to give
highly functionalized 4- oxothiazolidin-5-ylidene acetate derivatives. In this reaction,
both sulfur group and amino group are capable to react with DMAD. It was found that
thiourea react with DMAD exclusively with sulfur atom. The structure of the new
compounds was established by IR and NMR spectroscopy